Around 200 workers will be getting the boot, mostly from the Adelaide head office as the company seeks to tighten its belt.

The company said in a statement that the organisational changes are "consistent with the objective of the company's August strategic review to restore and maximise shareholder value".

In August CEO David Knox fell on his sword, and the company started to deal with its $8.8 billion in debt, putting all its assets up for sale.

Together with cost savings in its Cooper Basin heartland, the company is aiming to save around $100 million over the next three years.

"The job reductions are a part of a broader restructure of the Eastern Australia business to make it a leaner, more agile organisation delivering lower cost oil and gas from the Cooper Basin," the company said.

The company had already removed 565 workers since August, has halved its expenditure plans and cut its production costs by 11%.

Another 1000 contractor positions have also been shed, largely with the shift of the Gladstone LNG project from construction to development phase.

About 1400 employees will remain employed by Santos in South Australia following the latest cuts.

Santos is no orphan in sacking workers, with job losses across the economy.

The job losses come as South Australia's unemployment rate hits 8.2%, the worst in the nation and a 15-year high.

In the oil patch thousands of workers have been let go worldwide, as the sector reacts to low oil prices, the end of the construction boom and a reduction in exploration budgets.

Last week Chevron let go some 200 workers from its Wheatstone LNG project in Western Australia, in what the company designed as a "realignment of roles".

Contractor Bechtel said thousands more jobs will be created next year as Wheatstone ramps up.

Chevron has also cut staff on its global energy trading desks as part of a $3 billion cost-saving plan brought on by low crude oil prices.

The US super-major's Supply and Trading group, based in Houston, Texas, but with offices in Singapore, London and San Ramon, California, may be reduced by as much as 10% as part of a company-wide job reduction plan.

In July Chevron said it would lay off 1500 employees globally, about 2% of its workforce, with about two-thirds of those in Texas.

Chevron's trading desk handles an average of 5MMbopd of liquids, about 8% of daily global supply.

It also trades six billion cubic feet a day of natural gas, equal to about 7% of US daily supply.